Onasemnogene Abeparvovec Intravenous (Zolgensma®) Service & Onasemnogene Abeparvovec Intrathecal (OAV101 IT) Service
NHS EnglandEstimated Value
£753,000 – £1,036,000
Deadline
8 July 2026
Published
22 September 2026
Type
services
Overview
Intention to award the Onasemnogene Abeparvovec Intravenous (Zolgensma®) Service & Onasemnogene Abeparvovec Intrathecal (OAV101 IT) Service. This is a a one-time, in vivo gene replacement therapy, for use in babies aged 12 months and under, that utilises an adeno-associated virus serotype 9 (AAV9) vector, modified to contain a functional copy of the human SMN1 gene.
It is administered intravenously, allowing the vector to deliver the gene into motor neurones and peripheral tissues, enabling the sustained expression of survival motor neuron (SMN) protein, which is deficient or mutated in individuals with SMA. Onasemnogene abeparvovec intrathecal (OAV101 IT) is a one-time in vivo gene replacement therapy for patients with SMA, proposed to treat individuals with SMA aged 2 years and over.
This intrathecal injection will be used to treat a distinct cohort of SMA patients to Zolgensma. It will be assessed via NICE’s technology appraisal programme, with an expected final guidance publication date in late 2026.
Lots (3)
- Lot 1Zolgensma only (if no positive NICE recommendation for OAV101 IT)
- Lot 2Positive recommendation for OAV101 IT for paediatric patients (in combination with Lot 1 for Zolgensma)
- Lot 3Positive NICE recommendation for OAV101 IT for adult patients (either standalone or in combination with Lots 1 and 2) Additional information: Lot 3: Positive NICE recommendation for OAV101 IT for adult patients (either standalone or in combination with Lots 1 and 2)
Additional details
Procurement was carried out in Lots for the services as detailed above. Contract values are estimated and will be dependent on number of patients actually treated at each awarded provider.
AI AnalysisMembers
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The NHS is seeking to commission two gene therapy services for treating Spinal Muscular Atrophy (SMA): Zolgensma® for babies under 12 months (intravenous injection) and OAV101 IT for older children and adults aged 2+ (intrathecal injection into the spine). This is a highly specialised medical service requiring expertise in administering one-time genetic treatments that replace a faulty gene with a working copy.
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Award Details
Northern Care Alliance NHS Foundation Trust
£1,036,000
University Hospitals Bristol and Weston NHS Foundation Trust
£1,036,000
Sheffield Teaching Hospitals NHS Foundation Trust
£1,036,000
Oxford University Hospitals NHS FT
£1,036,000
The Newcastle upon Tyne Hospitals NHS Foundation Trust
£1,036,000
University Hospitals Southampton
£1,036,000
University College London Hospitals NHS Foundation Trust
£1,036,000
St George's University Hospitals NHS Foundation Trust
£1,036,000
KING'S COLLEGE HOSPITAL NHS FT
£1,036,000
Great Ormond Street Hospital
£1,036,000
Guy's and St Thomas' NHS Foundation Trust
£1,036,000
University Hospitals of North Staffordshire NHS Trust
£1,036,000
Sheffield Children's NHS Foundation Trust
£1,036,000
Leeds Teaching Hopsital NHS Foundation Trust
£1,036,000
North Manchester General Hospital
£1,036,000
AlderHey Children's NHS FT
£1,036,000
Likely incumbents
Suppliers who won similar work from this buyer in the last 5 years.
- 1
CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST
3 contracts wonlatest 7 Jul 2026£18m
total awarded
- 2
OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST
3 contracts wonlatest 7 Jul 2026£32m
total awarded
- 3
Sheffield Teaching Hospitals NHS Foundation Trust
3 contracts wonlatest 5 Jun 2026£779m
total awarded
- 4
The Newcastle upon Tyne Hospitals NHS Foundation Trust
3 contracts wonlatest 5 Jun 2026£793m
total awarded
- 5
MDSAS LTD
3 contracts wonlatest 19 Feb 2026£1m
total awarded
CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST is the most likely incumbent based on recency and category match. To win, bidders typically need a clearly differentiated proposition or a price advantage.
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Buyer Profile
NHS EnglandKey Dates
Published
22 September 2026
Submission deadline
8 July 2026
Notice type
award
Source
find a tender
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